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Circulating anticentromere CENP-A and CENP-B antibodies in patients with diffuse and limited systemi
Written by DaisyDo   
23 March 2010
Full title: Circulating anticentromere CENP-A and CENP-B antibodies in patients with diffuse and limited systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.    J Rheumatol. 2000 Jan;27(1):142-8.   Authors: 

Russo K, Hoch S, Dima C, Varga J, Teodorescu M.

Department of Microbiology/Immunology, College of Medicine, University of Illinois at Chicago, USA.

 

 OBJECTIVE: To determine the disease sensitivity and specificity of testing for autoantibodies against 2 of the 3 main human centromere antigenic components, CENP-A and CENP-B (recombinant, expressed in baculovirus).





Hits: 1337
Distinct recognition of antibodies to centromere proteins in primary Sjogren's syndrome compared wit
Written by DaisyDo   
17 March 2010
Full Title: Distinct recognition of antibodies to centromere proteins in primary Sjogren's syndrome compared with limited scleroderma.   From:  http://www.ncbi.nlm.nih.gov/pubmed/16414973   Ann Rheum Dis. 2006 Aug;65(8):1028-32.   Authors: 

Gelber AC, Pillemer SR, Baum BJ, Wigley FM, Hummers LK, Morris S, Rosen A, Casciola-Rosen L.

Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F Lord Building Center Tower, Suite 4100, Room 407, Baltimore MD 21224, USA. agelber@jhmi.edu

<abstract>

BACKGROUND: Anticentromere antibodies are characteristically observed in scleroderma but have recently been reported in other autoimmune rheumatic disorders, including Sjögren's syndrome. It is not known whether distinct centromere proteins (CENP) are targeted in primary Sjögren's syndrome (pSS) and scleroderma.

 



Hits: 772
Autoantibodies and microvascular damage are independent predictive factors for the progression of Ra
Written by DaisyDo   
17 March 2010
Full title: Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis.   From:  http://www.ncbi.nlm.nih.gov/pubmed/19035499   Arthritis Rheum. 2008 Dec;58(12):3902-12.      Authors:

Koenig M, Joyal F, Fritzler MJ, Roussin A, Abrahamowicz M, Boire G, Goulet JR, Rich E, Grodzicky T, Raymond Y, Senécal JL.

Notre-Dame Hospital, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.

<abstract>

OBJECTIVE: To identify in patients with Raynaud's phenomenon (RP) independent markers that predict progression to definite systemic sclerosis (SSc) and to determine in patients with progression to SSc the type and sequence of microvascular damage and its relationship to SSc-specific autoantibodies.

 



Hits: 758
Autoantibodies as predictive tools in systemic sclerosis.
Written by DaisyDo   
17 March 2010
from: http://www.ncbi.nlm.nih.gov/pubmed/20125179
Nat Rev Rheumatol. 2010 Feb;6(2):112-6. Authors: 

Nihtyanova SI, Denton CP.

Royal Free and University College Medical School, London, UK.

 <abstract>

The pathogenetic role of autoantibodies in systemic sclerosis (SSc) remains unclear, but these autoantibodies have been established as strong predictors of disease outcome and the pattern of organ complications in patients with this condition.



Hits: 697
Diagnosis and Classification of Systemic Sclerosis.
Written by DaisyDo   
17 March 2010
from: http://www.ncbi.nlm.nih.gov/pubmed/20143182
Clin Rev Allergy Immunol. 2010 Feb 10. Author:

Hachulla E, Launay D.

Department of Internal Medicine, National Scleroderma Center, Hôpital Claude Huriez, Université de Lille 2, 59037, Lille cedex, France, ehachulla@chru-lille.fr.

<abstract>

 As the diagnosis of systemic sclerosis (SSc) is generally suggested by the presence of Raynaud's phenomenon followed by typical skin thickening associated with the presence of additional extracutaneous features, capillaroscopic abnormalities, and characteristic autoantibodies, the first classification criteria, published by the American Rheumatism Association in 1980, were based only on clinical and chest X-ray items. As a consequence, 10% to 20% of the patients did not meet these criteria. In 1988, an international consensus was reached resulting in the proposal of a new and more practical classification based on the judgment and clinical practice of an expert panel. This classification introduced the SSc nail fold capillaroscopy abnormalities (dilation and/or avascular areas) and specific antinuclear antibodies.



Hits: 1034
 

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