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Genetic predisposition



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01/22/2008 09:10
BritChick
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Hi all,

Just wanted to raise something with you all...

I read the book 'All in my Head' by Paula Kamen, in which she brings together a lot of her research into headache as well as her own experiences, and she points out repeatedly that there has to be a genetic predisposition for someone to get migraines, or chronic headache. She doesn't think anyone in her family has any history of headache, and only much much later discovers that some second cousins or something have them.

I only bring this up because on reading this I thought 'no-one in my family has had headaches or migraines, but I know I'm not imagining this headache - so they must be wrong about the genetic predisposition.'

BUT - not so fast....my family'd never told me they had migraines!

I had asked my mother if she'd suffered from migraines or bad headaches (especially after my doctor said 'all headache is migraine'), and she said no, I couldn't remember my Dad saying anything about migraines before he died and nor could my Mum. None of my sisters and brothers - I'm one of 8, all the older ones are half-siblings from my mother and father's first marriage - had mentioned migraines or bad headaches to me before I got ill, and didn't tell me they suffered from migraines after I got ill either.

I had simply assumed they would tell me if they had migraines when I was suffering from a debilitating headache so as to raise the possibility of it being genetic, but they didn't make the connection.

I only started asking after one of my older half-sisters (my mother's daughter) made a chance remark about her migraines, and now it turns out that one of my half-sisters from my father's first marriage also has them, and my youger full sister had some 'classic' migraines during puberty, so it must be coming from somewhere in my family, may even have skipped a generation, and seems to have come out in a particularly nasty fashion in me!

So, if you don't know or it's never been mentioned, it might be worth double-checking with your family because I realised that, even though these three had migraines from time to time, they had virtually no information about migraine or headache (and some of what they think they know is old wive's tales).

I'm the one with all the knowledge because of getting the really nasty headache which frustrated me enough for me to do some proper research. But it does make me feel better because at least it indicates some sort of cause for the headache, which was then triggered by other things.

Anyway, it's just a cautionary tale from a big family - never assume people will make useful connections if they have information you need, the connections they make are likely to be the totally irrelevant ones about what helped their flatmate's brother's girlfriend with a completely different illness

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01/22/2008 10:34
bgcmom
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BritChick~

The doctors all asked us if there was a family hx. of headaches on either side of our families. We asked around and NONE. My husband did have a history of carotidena...which is like a migraine in the neck (?). They weren't sure that would be a predisposing factor for her or not, just commented that it was "interesting". He suffered w/this for 6 years. (but was treated by ENT, not a neurologist--surprising they caught it) He took a mini-dose of Elavil 10mg. It didn't help. (our neuro said it wouldn't have, it should have been Indocin). His problem just resolved. Interestingly, we noticed when we went to Colorado for our honeymoon, when we drove into higher altitude, the pain left and stayed gone, until we drove back down to lower altitude. (Makes me wonder if another Colorado trip, or move, is in order! Wonder if altitude makes a difference for her?)

So, not sure if that was a predisposing thing for her or not.

I did however find an interesting article about a predisposing factor of NDPH. It was interesting to me because many on my husband's side of the family are hypermobility of joints. (double-jointed..oddly). For ex: My daughter (the one who has NDPH) is double jointed in her first joint on all her fingers and can naturally bend her fingers at the first joint. She is very flexible and double jointed other places as well. I googled hypermobility of joints after reading the following article and found links to RA. My daughter was tested for RA and Lupus. Both negative. They tested her b/c of a POSITIVE ANA. Just wondered if anyone else has a POSITIVE ANA with a SPECKLED PATTERN. Hers doubled in the first 2 weeks of the headache---no explanation---and we haven't retested, since all the work-up was inconclusive. So, anyone else here have +ANA w/Speckled pattern? And, does the following article mean anything to anyone else w/NDPH???

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

****Read this article at the following link:****

CEPHALALGIA : AN INTERNATIONAL JOURNAL OF HEADACHE Vol. 26 Issue 10 Oct 2006

Link: http://www.searchmedica.com/primarycare/EUICachedXML.do? hl=none&cacheid=ds3-vb src="http://www.mdjunction.com/components/com_joomlaboard/ emoticons/tongue.png" alt="" style="vertical-align: middle;border:0px;" />:2013t:81340366464:b558fa61ee3cd681:47426844&template_id=pubmed.com&scopeid=defLink&useraction=viewCachedXML

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Hope this didn't get too off-topic with the questions you asked, BritChick! It is still about predisposing factors.

Hopefully more research will be done and they soon will come up with answers that mean something will lead to a CURE for NDPH.

Post edited by: bgcmom, at: 01/22/2008 19:34

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01/22/2008 15:24
MaryR
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I did not know I had family history of headaches until I got my first major one. Then I was filling out the forms in the neuro's office and my Mom told me that my maternal grandfather had cluster headaches for years. He died when I was very little so I never knew about it and I don't think anyone would have thought to mention it if I had not had a severe headache myself. It makes me wonder what else I don't know.

I also have hypermobility of the joints and would have a high Beighton score (I looked it up online and evaluated myself...cheating I know, but I was curious). I don't know how this relates to NDPH but if it is a predisposing factor there have to be others in play as well. My twin sister has the same Beighton score as I do (we had a bit of a friendly competition going) but no headache. My little sister is not as high of a scorer and does not have a headache. I am very interested in anything and everything that might lead to understanding where this comes from in the hopes that it would lead to understanding how to make it go.

Mary
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01/22/2008 18:58
Sahara18
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Christina has two cousins who have migraines- they are her dad's 1st cousins. There is a STRONG history of depression on his side also, like everyone, cousins, aunts, uncles, mom, brother. One of the two cousins w/migraines is 22 yrs old and last year, after going over her 2 MRI's several times,MDs found that she has arthritis in her occipital joint. The other is 44 and is also bipolar. Christina also has hypermobility and the pediatric neurologist who saw her in the ER in Jan. 2005 did a physical exam that included checking for Marfan Syndrome, which he concluded she did not have. Her AC joint in her right shoulder separates more than 2 cm. Her ligaments are intact (no surgery required-just physical therapy, which made it hurt more), but her collar bone pops out of joint...it's really gross! She also has synovitis in her knees, basically not much fluid btwn joints and the are sometimes swollen and hurt, especially before it rains...arthritis related? I recall someone else in this group saying they had hypermobility...was it flashinmyeyes, the 16 yo? Her neurologist and her orthopedist have not said that the two are related, but we really think they are somehow. Definitely worth more research.
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01/25/2008 18:38
Sahara18
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I found this website while searching for hypermobility info. http://www.hypermobility.org/beighton.php It's very informative. I'm surprised to find that others have this along w/headaches. I think I'm going to ask the MDs more ?s about this.
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01/26/2008 14:28
bgcmom
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I am also planning to ask our Pedi-headache specialist about this! I thought it was interesting when I found it, and even more interesting to find that others have the hypermobility!

So glad we have this site to bounce thoughts and ideas off each other!!! Who knows,together we may find THE FIX!!!

bgcmom
Ronda

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01/27/2008 13:15
sailingmuffin
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Hi All,

I am about 95% certain that there is a genetic predispition to migraines/ CDH/ and NDPH. Furthermore, after my headaches became chronic at age 17, now 27, I learned that several close relatives had migraine, though theirs were not as severe.

My father's mother got "sinus headache", but it is pretty clear they were migraine- she had all of the symptoms, but there were certainly not as many treatment options then, and it was not something you could talk about.

My parents had been married for 10 years before she found out that he had migraine. She noticed that he never travelled without Aspirin and one day she saw him writing something in a small book and Dad said that he was simply keeping track of the migraine. Dad no longer has pain with migraines, but he has some other symptoms. Apparently, the pain disappeared but some of the other symptoms did not. So, it is quite possible to have this kind of predisition and not know it.

My neuro is really interested in the genetic component of migraine-doing research on it and stuff. It will be interesting to see if anything comes of it. Meanwhiloe, he is a great neuro.

I hate the fact that we have to deal with this, and sometimes, it would be helpful to know that you are not the only one in the family with it. Also, some may not know that they have migraine at all.

Anyway, those are my thoughts.

Pain free days,

sailingm



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01/28/2008 11:28
Magnus
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No headaches in my family. But hypermobility - yes, I do have that.

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01/29/2008 18:20
Sahara18
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Researchers have actually already found a genetic marker for migraines, but unfortunately, I think that is as far as they have gotten. They are also working on an eighth "triptan" med- Donitriptan. I'm not sure when it will be out. There isn't much info on the internet...I read the fine print in an abstract. I'll ask our Neuro about it and let y'all know what I find out.My daughter has tried 6 of the seven and none of them work for her.
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01/30/2008 06:23
Sahara18
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Hey, I found the websites for the above mentioned...

"Scientists believe they have discovered the genetic marker..."

http://headaches.about.com/library/weekly/aa- encouragement.htm

"...is developing donitriptan..."

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=11575714

Post edited by: Sahara17, at: 01/31/2008 20:48

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