Been having horrible all-over joint, muscle, nerve pain. Can't even describe it.New pain management doc prescribed a topical cream made by a compounding pharmacy. It is amazing. Really helps, right away. No waiting. Much fewer side effects than systemic meds. Doesn't suppress immune system like systemic meds either.
Pain cream ingredients
Keta/baclo/cyclo/diclo/gaba/tetracaine
• Ketamine –analgesic, anaesthetic for nerve pain
• Baclofen – muscle relaxant – agonist for GABA receptors
• Cyclobenzaprine – muscle relaxant, also related to tricyclics
• Diclofenac (NSAID)
• Gabapentin – for use for neuropathic and migraine pain. GABA analogue
• Tetracaine – local anesthetic
article that he co-wrote is here:
http://onlinelibrary.wiley.com/doi/10.1111/j.1526-
4637.2010.00809.x/abstract
Topical NSAID Therapy for Musculoskeletal Pain
Simon Haroutiunian MSc1,2,*, Daniel A Drennan MD3, Arthur G. Lipman PharmD1,3
Article first published online: 4 MAR 2010
DOI: 10.1111/j.1526-4637.2010.00809.x
Wiley Periodicals, Inc.
Issue
Pain Medicine
Volume 11, Issue 4, pages 535–549, April 2010
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How to Cite... click on these 3 titles to read more!
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Publication History
Haroutiunian, S., Drennan, D. A. and Lipman, A. G. (2010), Topical NSAID Therapy for Musculoskeletal Pain. Pain Medicine, 11: 535–549. doi: 10.1111/j.1526-4637.2010.00809.x
Author Information
1Department of Pharmacotherapy, College of Pharmacy, University of Utah
2Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Israel
3Department of Anesthesiology, School of Medicine; and Pain Management Center, University Health Care, Salt Lake City, Utah, USA
*Simon Haroutiunian, MSc, Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Tel: +972-26757667; Fax: +972-26757246; E-mail: simonh@ekmd.huji.ac.il.
Publication History
Issue published online: 31 MAR 2010
Article first published online: 4 MAR 2010
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View Full Article (HTML) Get PDF (214K)Keywords:NSAID;Nonsteroidal;Topical;Pharmacokinetics;
Pain;Musculoskeletal
Abstract
Objective.
Systematic reviews previously reported in the literature document that topical nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in relieving pain in acute and chronic painful musculoskeletal disorders including osteoarthritis, tendonitis, and muscle strains.
Because several topical NSAIDs are available, with important differences among the formulations, there is a need to address and summarize the evidence of their effectiveness and safety.
Design.
We searched Medline and Cochrane CENTRAL databases for clinical trials and systematic reviews of topical NSAIDs in musculoskeletal pain, using the following keywords:
“NSAID,”“nonsteroidal,”“anti-
inflammatory,”“topical,”“cream,”“gel,”“solution,”“lotion,”“p
atch,” plaster,”“musculoskeletal,”“tendonitis,”“strain,”“sprain,”“t
rauma,” and word roots “pain” and “arthritis.”
Conclusions.
Topical NSAIDs may vary significantly in their absorption kinetics and pharmacodynamic effects, based on NSAID molecule and the formulation chosen.
Some topical NSAID formulations have been shown to be more effective than placebo in multiple studies, or to have comparable efficacy and a better safety profile than oral NSAIDs for single joint osteoarthritis and acute muscle injuries.
In acute and chronic low back pain, widespread musculoskeletal pain, and in peripheral neuropathic pain syndromes, the current evidence does not support the use of topical NSAIDs.
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bettyg, leader added the article above.
Lasts for about 6 hours, but I'm finding that it seems to interrupt the pain cycle, so I don't have to use it every day, except on my knees.
