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11/02/2007 03:19 PM

Fibro and Poo (sorry)

Posts: 24

The following information was received from Dr. Rodger Murphree. I have been following this for a couple of weeks and have seen some marked improvement. If you already have diarrhea though you really need to watch the level of magnesium. Hope that this information helps someone else.

40 Million Americans have been diagnosed with irritable bowel syndrome (IBS). Several patients suffering with Fibromyalgia also suffer from IBS.

Some experts report that IBS affects approximately 10-20% of the general population. IBS is characterized by a group of symptoms in which abdominal pain or discomfort is associated with a change in bowel pattern, such as loose or more frequent bowel movements or diarrhea, and/or less frequent bowel movements or constipation.

Gender plays a clear role, as more than 80% of IBS patients are women between the ages of 20 and 55 years old.

The criteria for diagnosing IBS is based on the newly modified Rome criteria (Rome II criteria) as the presence for at least 12 weeks (not necessarily consecutive) in the preceding 12 months of abdominal discomfort or pain that cannot be explained by a structural or biochemical abnormality and that has at least two of the following three features:

(1) pain is relieved with defecation, and its onset is associated (2) with a change in the frequency of bowel movements (diarrhea or constipation) or (3) with a change in the form of the stool (loose, watery or pellet-like).

Some people with the disorder have constipation (IBS-C). Some have diarrhea (IBS-D). And some alternate back and forth between the two (IBS-A)

IBS symptoms result from what appears to be a disturbance in the

interaction between the gut or intestines, the brain, and the

autonomic nervous system that alters regulation of bowel motility

(motor function) or sensory function.

Research has shown that the cause of IBS is related to neuroendocrine

immune system dysfunction (brain and stomach hormones). This

connection is largely mediated by the neurotransmitter serotonin. The

brain and gut are connected through the neuroreceptors

5-hydroxytriptamine-3 (5-HT3) and 5-hydroxytriptamine-4 (5-HT4).

These serotonin receptors regulate the perception of intestinal pain

and the GI motility (contractions that move food through the

intestinal tract). Therefore serotonin controls how fast or how slow

food moves through the intestinal tract. In fact, there are more

serotonin receptors in the intestinal tract than there are in the

brain. Ninety percent of serotonin receptors are in the intestinal


Research suggests that IBS patients have extra sensitive pain

receptors in the gastrointestinal tract, which may be related to low

levels of serotonin. Decreased levels of serotonin may help explain

why people with IBS are likely to be anxious or depressed. Studies

show that 54–94% of IBS patients meet the diagnostic criteria for

depression, anxiety, or panic disorder.

Restoring optimal levels of serotonin has been the focus of

traditional drug therapy. Zelnorm, a 5-HT4 receptor agonist, was once

hailed as “the drug” for IBS-c (IBS with frequent constipation), has

recently pulled from the market for its association with heart attacks

and stroke. The percentage of patients taking Zelnorm that had serious

and life-threatening side effects was 10 times higher than the

percentage of patients taking a placebo.

Even before this drug was recalled cardiovascular risks, many experts

warned that this drug was dangerous for its other potential side

effects including severe liver impairment, severe kidney impairment,

bowel obstruction, diarrhea, constipation, abdominal pain, headaches,

abdominal adhesions, gallbladder disease, and back pain.

Lotrinex (Alosetron), a 5-HT3 agonist, is prescribed for IBS-d. Within

8 months of being on the market, reports of ischemic colitis (a life

endangering situation in which the blood supply to the intestines is

blocked) began to grow each day. Lotrinex was responsible for at least

four deaths, probably many more. Many who took the drug reported

severe abdominal pain from constipation.

The drug was taken off the market. It is now back and available with

strict prescribing guidelines. An editorial in The British Medical

Journal suggests that as many as 2 million Americans will be eligible

for the drug under the new guidelines. According to previous reported

side effects, this would result in 2,000 cases of severe constipation,

almost 6,000 cases of ischemic colitis, 11,000 surgical interventions,

and at least 324 deaths.

Antispasmodics (Levsin, Levsinex, Bentyl, Donnatal, etc.) are

routinely prescribed for the treatment of IBS symptoms. Potential side

effects include bloating; blurred vision; clumsiness; constipation;

decreased sweating; dizziness; drowsiness; dry mouth; excessive

daytime drowsiness ("hangover effect"Wink; feeling of a whirling motion;

headache; light-headedness; nausea; nervousness; rash; hives;

difficulty breathing; tightness in the chest; swelling of the mouth,

face, lips, or tongue agitation; confusion; diarrhea; difficulty

focusing eyes; disorientation; exaggerated feeling of well-being;

excitement; fainting; fast or irregular heartbeat; hallucinations;

loss of coordination; loss of taste; memory loss; muscle pain;

pounding in the chest; severe or persistent trouble sleeping; trouble

urinating; unusual weakness; very slow breathing; vision changes;


Why in the world would someone prescribe this crap? (Pun intended.) It

is absurd to suggest that individuals with IBS have a drug deficiency.

IBS is not a disease; it is a symptom of a compromised

gastrointestinal system. Using potentially dangerous drugs to reduce

symptoms, while ignoring natural and often more effective approaches

is typical of what is wrong with “cookbook” (symptom-focused)


------------------------------------------------------------ -------------

Reversing IBS with nutritional therapy

------------------------------------------------------------ -------------

I find that IBS usually disappears rather quickly once my patient's

correct their poor eating habits (increase fiber, reduce simple

sugars, caffeine and junk foods), uncover any hidden allergies when

present, including gluten intolerance (Celiac disease), boost optimal

stress coping chemicals (serotonin, magnesium, B-vitamins, etc.),

restore bowel ecology (probiotics), and take digestive enzymes with

their meals.

------------------------------------------------------------ -------------


To boost serotonin levels I recommend patients take, the amino acid

responsible for making serotonin, known as 5-hydroxytryptophan (5HTP).

Patients should take 300-400mg a day with food.

------------------------------------------------------------ -------------

Digestive enzymes

Most digestion and absorption takes place in the small intestine and

is regulated by pancreatic enzymes (digestive) and bile. The pancreas

aids in digestion by releasing proteolytic enzymes, which help break

down proteins into amino acids. Natural digestive enzymes are found in

raw fruits and vegetables. Processed foods are usually devoid of

digestive enzymes.

Over consumption of these processed foods can lead to digestive enzyme

deficiencies. This may then lead to malabsorption and or intestinal

permeability syndrome (bloating, gas, indigestion, diarrhea,

constipation, and intestinal inflammation). To ensure proper digestion

and absorption, I recommend taking pancreatic enzymes with each meal.

------------------------------------------------------------ -------------


I always recommend people take a good optimal daily allowance

multivitamin/mineral formula. Patients with IBS have depleted their

stress coping chemicals and this not only leads to IBS but also

prevents them from beating IBS. It is a vicious cycle that can only be

broken by taking adequate amounts of essential vitamins and minerals.

The mineral magnesium, which is involved in over 300 bodily processes,

is particularly important for reversing the symptoms of IBS-c.

Magnesium helps relax the smooth muscle of the colon (natural

laxative) allowing normal bowel movements. While a diet high in

nutritious fiber is important, magnesium is even more important. A

magnesium deficiency not only causes constipation but can also lead to

heart disease, mitral valve prolapse (MVP), depression, anxiety,

chronic muscle pain, headaches, migraines, fatigue, and many other

unwanted health conditions. Those with IBS-c may need up to 1,000mg of

magnesium each day. While those with IBS-d, may need less than 500mg.

I recommend patients begin with 500mg of magnesium a day.

------------------------------------------------------------ -------------


The human intestines are inhabited by billions of beneficial bacteria.

These bacteria, which are mostly located in the colon, aid in

digestion by fermenting substances that were not digested in the small

intestine and by breaking down any remaining nutrients.A healthy

intestinal tract contains some 2-3 lb. of bacteria and other

microorganisms, such as yeast, that normally don't cause ay health


However, when the intestinal tract is repetitively exposed to toxic

substances (antibiotics, steroids, NSAIDs, etc.), these microorganisms

begin to proliferate and create an imbalance in the bowel flora.

Harmful organisms like yeast and some normally dormant bacteria, begin

to overtake the good bacteria. This is known as intestinal dysbiosis.

IBS and small-intestinal bacterial overgrowth may share similar

symptoms. One study showed that 78% IBS participants had

small-intestinal bacterial overgrowth. To aid in digestion and prevent

intestinal dysbiosis, patients with IBS should take probiotics

(Lactobacillus and Biidobacterium) on a daily basis.

This approach isn't guaranteed to solve every case of IBS. However, in

the majority patients, symptoms improve to such point that

within a few weeks they can focus on more important topics.[size=2][/size]

Post edited by: JaScott007, at: 11/02/2007 17:20


11/02/2007 03:25 PM
Posts: 467

can't comment on the science but defiantly worthy of being a sticky

Thanks JA!

11/02/2007 03:28 PM
Posts: 1079
Senior Member


The secret FINALLY comes out JaScott!!! Thank you for the info...that's very helpful!


11/02/2007 08:32 PM
Posts: 226

Thank you so much, JaScott! The information was very valuable. I'm glad to know I'm doing something right. I take 5-HTP, Magnesium, and Probiotics. I need to work on my fiber consumption.

My brother is allergic to wheat. Do you think, I could also be allergic to wheat? It sure would explain a lot of my symptoms. Smile

11/03/2007 01:29 AM
Posts: 24

Yes- Gluten allergy can cause a lot of problems and some symptoms similiar to fibro. It can also cause problems with you being able to absorb minerals through normal means. If that is the case then you are absorbing very little of the supplements you are taking. If your body is not absorboing B-12 and Magnesium- that would go a long way toward explaining your tingling feelings and other symptoms you told me about.

You should have a Celiac panel (blood test) done as soon as you can. If that comes up negative thereis another test that is a fecal test that is actually supposed to be more accurate than the blood test. Make sure if you go for the Celiac panel that you continue your normal diet as well as eat some gluten based products prior to the test. If your brother is allergic to wheat I would bet that there is a good chance you are as well. It often runs in families. I would certainly examine that route. Let me know

11/03/2007 08:47 AM
Posts: 226

What specialist would I need to see? I don't believe my Family Medicine doctors tests for Celiac Disease. Should a see an Internal Medicine physician?


Honey Smile

11/03/2007 08:58 AM

Since Celiac Disease is associated with the intestines, maybe you should go to a Gastroenterologist for testing.

Family Medicine Doctors are fine for minor conditions. My Family Medicine Doctor was just diagnosed with MS about a year ago. Since then, she's more aware of symptoms and pain and she won't hesitate to send you to a specialist if she feels it's out of her hands. I found most Family Medicine Doctors are reluctant to make a formal diagnosis because of malpractice or misdiagnosed conditions.

04/05/2008 07:23 PM
Posts: 90

Excellent information JaScott!!!!! and I can testify to the science of it!

I hope a lot of people read this, thank you for sharing it Smile

05/06/2008 08:29 PM
Posts: 6

Ever since my flare up two days ago I am experiencing the bloating and the "runs" and the constipation.

Tried eating yogurt and drinking water, vitamins and potassium( I take a beta blocker and a diuretic for my bp) this condition has interfered with my workouts, it is really bugging me!!


05/07/2008 07:20 AM

Patricia, a long time ago I was put on a diet and experienced the constipation and the bloating and runs. My doctor told me to sprinkle a teaspoon of bran on my food. She said that the good thing about bran is that it will regulate both constipation and the trotts.



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