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Thanks for sharing this link. I found it on a couple of other websites and it looks like this drug was approved for use as "Cesamet" in the U.S. in 2006-- however, it is a C-II controlled substance used primarily to treat the nausea from chemo in cancer patients when nothing else has worked, it has a lot of serious side effects, and it has a lot of drug interactions with some very common drugs that fibro patients might be taking. It sounds like the DEA might be monitoring the use of this one very carefully because of its high addiction potential and the fact that it is chemically like marijuana. God forbid anyone get high while they are getting pain relief! Sounds like this one might be good for night time pain relief though.... http://www.multum.com/nabilone.htm Nabilone capsules CESAMET™ FDA Approval: 16 May 2006 Indication: Cancer chemotherapy-associated nausea and vomiting when conventional antiemetics have been ineffective Pharmacology: Synthetic cannabinoid Usual Dose: 1 to 2 mg orally twice a day. Give 1 to 3 hours before antineoplastics on chemotherapy days. Contraindications: Hypersensitivity to cannabinoids Warnings: Psychiatric side effects may occur for up to 48 to 72 hours after discontinuation CNS side effects may include dizziness, drowsiness, euphoria, ataxia, anxiety, disorientation, depression, hallucinations, and psychosis Patients should be supervised by a responsible adult while taking nabilone May cause tachycardia and orthostatic hypotension Patients should not drive, operate machinery, or engage in other activities requiring mental alertness and coordination Alcohol, sedatives, hypnotics, and psychoactive agents should be avoided Caution is recommended in the elderly, hypertension, heart disease, psychiatric disorders, history of substance abuse, concomitant use of CNS-active drugs, pregnancy, breastfeeding, and pediatric patients Safety has not been established in renal and liver insufficiency CSA schedule II Pregnancy Category: C Side Effects: Most common: drowsiness, vertigo, dry mouth, euphoria, ataxia, headache, difficulty concentrating Drug Interactions: amphetamines, cocaine sympathomimetics anticholinergic agents tricyclic antidepressants CNS depressants disulfiram fluoxetine barbiturates theophylline opioids naltrexone alcohol |
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