Osiris Prochymal Stem Cell Transplant Update and XBP1 Info So I have to think that I got more than a placebo. While on the high level I am more relaxed, happy and content than I though possible, I am also under a lot of day-to-day stress and pressure. As almost anyone with Crohn's Disease will tell you, there is a near concrete link between stress and Crohn's Disease flare ups. With my recent stress levels, I am pretty confident that pre-Osiris Prochymal I would be in a flare up. The good news is that I am not. The pain has subsided quite a bit and I am generally feeling really great as it relates to Crohn's. My improvements were enough to qualify me for phase II and as soon as I enter a flare-up, I am ready for 4 more treatments. I am more living with Crohn's now than I am suffering from it, and that is a big step in the right direction! Anyways, to you guys that are in Crones flare-ups or have been recently diagnosed....keep your heads up...and let me know if you have any questions. Be sure to use the search feature on this blog as we have covered alot of topics over the years. -Scottie PS - Intersing info here exploring the genetic link to Crohn's A team of scientists have discovered that the XBP1 gene is a risk factor for developing Crohn’s disease and ulcerative colitis, forms of inflammatory bowel disease (IBD). The investigators created a mouse model in which they deleted XBP1within the epithelium. They found that the mice spontaneously developed an intestinal inflammation that resembled IBD. The lack of the XBP1 gene disabled the normal communication between intestinal epithelial cells and gut bacteria, resulting in dysfunctional immune response and disease, the researchers explain. The researchers then reportedly demonstrated that alterations in this gene in the intestinal-lining cells represent risk factors for development of Crohn's and colitis. The study was conducted by scientists from Brigham and Women's Hospital, Harvard Medical School, and institutes in Germany, The Netherlands, and Austria. Results appear in the September 5 issue of Cell. |
