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08/14/2011 11:27 AM
jimmyw
Posts: 36
New Member

With cirrhosis which is usually higher the AST or the ALT. A Doctor mentioned something about the ratio.
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08/14/2011 02:18 PM  Top
iwiham1027
iwiham1027  
Posts: 686
Member

I was told it is the ALT L=Liver if this helps. Cheryl

08/14/2011 02:47 PM  Top
mike3232
Posts: 53
Member

I have read a greater than 1 ratio with cirrhosis with AST higher????

Post edited by: mike3232, at: 08/14/2011 02:48 PM


08/14/2011 04:02 PM  Top
bjlvls
bjlvls  
Posts: 1006
Senior Member

AST/ALT stands for aspartate aminotransferase/alanine aminotransferase. The ratio is sometimes useful in differentiating between causes of liver damage.

When the ratio is larger than 2.0, it is more likely to be associated with alcoholic hepatitis. When it's less than 1.0, it is more likely to be associated with viral hepatitis.

The ratio not so useful when the liver enzymes are not elevated, or when other conditions are present.

Life is too short to wake up with regrets. So love the people who treat you right..Forget about, scratch that, Pray for the ones who don't. Believe everything happens for a reason. If you get a second chance, grab it with both hands. If it changes your life, let it. Nobody said life would be easy, they just promised it would be worth it!-Catherine Yen

Previous discussions I participated in:
Liver biopsy and Labs
PANCEITISI
Changing regions

08/14/2011 04:09 PM  Top
mikealpha1
mikealpha1  
Posts: 2068
Group Leader

I knew we could count on you, Bobbi, to get those details straight. Here's a web-site that talks about it. http://www.medicinenet.com/liver_blood_tests/page2.htm.
Peace be with you,

Mike

08/15/2011 03:09 PM  Top
sadlystillsane
sadlystillsane  
Posts: 942
Member

I have always been told that the alkaline phosphate (ALP) is the one that is prognostic in nature....and that ALT/AST numbers are less significant? Or maybe that is just with PBC??
Take your time to smell the roses, and always follow your heart.

08/15/2011 04:15 PM  Top
bjlvls
bjlvls  
Posts: 1006
Senior Member

In the context of liver disease, higher ALP values generally indicate a greater degree of blockage in bile ducts.(Common among PBCer's)
Life is too short to wake up with regrets. So love the people who treat you right..Forget about, scratch that, Pray for the ones who don't. Believe everything happens for a reason. If you get a second chance, grab it with both hands. If it changes your life, let it. Nobody said life would be easy, they just promised it would be worth it!-Catherine Yen

Previous discussions I participated in:
Liver biopsy and Labs
PANCEITISI
Changing regions

08/15/2011 11:48 PM  Top
rpooo
rpooo  
Posts: 96
Member

The ratio is irrelevant to patients with out hepatitis.

AST (Aspartate Phosphatase) Lab Results

This test is typically used to detect a liver injury or an active or chronic liver problem. The heart can also release AST, so it is important to look at the entire set of liver tests, rather than just this one test. AST levels can be dramatically affected by shock, low blood pressure or any other condition that deprives the liver of blood and oxygen.

Normal Level:

Male: 8-46 units/liter

Female: 7-34 units/liter

ALT (Alanine Aminotransferase) Lab Results This test is used to detect liver injuries and long-term liver disease.

Highly elevated levels may indicate active hepatitis from any cause, including virus, alcohol, drug or toxin. Some prescription and over-the-counter medications can cause an increase in ALT levels. ALT levels can be dramatically affected by shock, low blood pressure or any other condition that deprives the liver of blood and oxygen.

Normal level: 5-40 units per liter of blood serum

Gamma-glutamyl transpeptidase (GGTP) or transferase (GGT)

Gamma-glutamyl transferase (GGT) is an enzyme which is useful clinically when compared to ALP. By comparing the two, it can be determined if the patient has bone or liver disease. It will describe the over-all liver function to include alcoholism and many other diseases. In short it detects general cellular damage.

GGT or GGTP normal range is 0-51 IU/L.

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