Ankylosing Spondylitis Support Group

Does anyone on here take Methotrexate to help with AS?? My doctor is suggesting that I start once a week injections and I just wanted to know if anyone takes them, how they do on the drug, what kind of side effects I can expect, how does it make you feel afterwards???? Thanks in advance for your response.

I used to take methotrexate once a week I'd take eight 2mg. tablets, but did not do very well on them...the side effects for me was that my hair and SKIN became thin; my hair woul break off which I can deal with but my skin was so thin, i would get major wounds from small scratches that couldn't heal due to the immuno-suppressant effect of the drug itself!!! I wouldn't write it off though, as all AS pts react differently to diff treatments and u r getting it injected which changes the reaction....biologic agents like Humira and Remicade have worked to ease some of my AS symptoms....good luck

I just started this in pill form and really have not noticed much difference yet.

I was diagnosed with AS in 2002. I have been taking Methotrexate (6-2.5 tabs) and using Enbrel for most of the time.

I've done very well on it and and have not had any side effects. I do take a high dose of Folic Acid which may contribute to not having side effects.

I am also takin Folic Acid daily and have had no side effects for Methotrexate.