What is the evidence base for the specific groups of medications used for PTSD treatment?Selective Serotonin Reuptake Inhibitors (SSRI's) These medications are the only FDA approved medications for PTSD. SSRIs primarily affect the neurotransmitter serotonin which is important in regulating mood, anxiety, appetite, and sleep and other bodily functions. This class of medication has the strongest empirical evidence with well designed randomized controlled trials (RCT's) and is the preferred initial class of medications used in PTSD treatment (1, 2). Exceptions may occur for patients based upon their individual histories of side effects, response, and comorbidities. An example of an exception would be a PTSD patient with comorbid Bipolar Disorder. In this patient, there is a risk of precipitating a manic episode with the SSRI's. Each patient varies in their response and ability to tolerate a specific medication and dosage, so medications must be tailored to individual needs. Research has suggested that maximum benefit from SSRI treatment depends upon adequate dosages and duration of treatment. Treatment adherence is key to successful pharmacotherapy treatment for PTSD. Examples of the SSRI's and some typical dosage ranges are listed below: Sertraline (Zoloft) 50 mg to 200 mg daily Citalopram (Celexa) 20 mg to 60 mg daily Paroxetine (Paxil) 20 to 60 mg daily Fluoxetine (Prozac) 20 mg to 60 mg daily Note: Only Sertraline and Paroxetine have been approved for PTSD treatment by the FDA. All other medications described in this guide are being used "off label" and may have empirical support but have not been through the FDA approval process for PTSD. http://www.ptsd.va.gov/professional/pages/clinicians-guide-
to-medications-for-ptsd.asp I desire to inspire before I expire. |
"The part of my recovery plan that I would say made up 80% is MDJ. I suffered a lot prior to finding MDJ, felt alone and had no one to talk to who really understood me. In the Bipolar Group I found like minded individuals who I could relate to and who offered support to me when I needed it. As I recovered, I could then offer support to them which gave me a good feeling about myself. I have met some great people here who I would class as good friends and know I would still be in the slump I was in without them. Now I am stable, I know that MDJ plays an important part in keeping me that way. Thank you MDJ for being there for us all and making us no longer feel alone." (liamacker)
