All theory/science/maths stuff. Good question. If you had the same energy value (kj/kcal)and efficiencies of the high vs low glycemic diet and the system was working perfectly I'd say that on a cortisol production rate per (long) time period would be the same. (ie milligrams per hour kind of measurement) You'd just find that in terms of instantaneous measured levels insulin would be high for high GI foods, less for low GI foods and low when not post eating. It would then follow that cortisol does roughly the reverse. It's always a balance thing though. AS a side note there is a distinction between "level" and usage. It is well known that major exercise may double the level, but that doesn't mean double the amount of cortisol produced. It depends on creation vs usage rates. If they are the same for example, the level wont actually change. I suspect (but don't know) that double the level actually implies 4x the creation rate. That is the number you then use for replacement dosing. In terms of dosing I'd say no or very little difference in dosing. Just an opinion mind you. There is no way you can emulate a natural cortisol system dynamics anyway. The pills just aren't fast enough. You can of course play with the overall tuning to flatten BG somewhat. It would be horribly complex though. Kind of like doing BG testing for insulin injections, but far more often. Imagine deciding on an optimum BG value, measuring every 20 minutes or so and if below it popping 0.5mg HC tablets when needed! It's just not feasible. Always wondered about adapting an insulin pump though. I of course don't have a handle on the relative efficiencies of fat vs starch etc food types, nor how much absorption of "other things" is impaired in an AI person. It's probably better to take the long term view, balancing exercise capabilities, fatigue and weight change.. Get some more opinions though! Please remember that accurate answers often need detailed source information. Please considering putting your DX status, drug dosage and other information into your "About Me" or Signature Line. That also includes what country you are in because measurement systems and diagnostic methods vary around the world.
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