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New to Epilepsy? Understanding Seizures
Written by urmine   
14 November 2012

This is for anyone who is new to this site and/or new to epilepsy and might be confused about what type of seizures they are having. Hope it helps!



Hits: 305
Attitudes
Written by 2steveb   
04 July 2010
Attitudes-?ours and how they can affect our seizures

Hits: 1234
the role of gut brain axses in seizure control
Written by paolomainardi   
22 October 2009

Usualy brain effects are studied when we are looking for new antiepileptic drug. All new potential neurological drugs are tested in slice of brain, on patch-clamping on isolate neurons, in next time on MES, in audiogenic animals, and so.

New drugs had to have the ability to open and close ionic channels of neuronal membrane, to decraese excitabilty and to increase inhibitory system.

But, when they are oral adiministred they have to reach the brain in the right concentration to develop the same effect observed in vitro.

 Since '70s antidepressant SSRIs are suggested to treat depression, the mechanism proposed is to increase the time of action of serotonin in synaptic cleft, but today (this year) Costa, Guidotti and Pinna found that at the low doses that these drugs reach the brain they are not able to inhibit.serotonin re-uptake. At these low doses they are able to stimulate neursteroid synthesis.

An house of cards seem falling down, but in the intestinal brain these drugs, orally adiministred, are in higher concentrations than in the brain, then in intestinal brain they are able to inhibit serotonin reuptake. Neuroendocrine system response is to increase brain synthesis of neuropeptides.



Hits: 1333
New ideas are needed to solve drug-resistant (Losher)
Written by paolomainardi   
21 October 2009
In spite of the large number of antiepileptic drugs (AEDs) actually available, the problem of drug resistant epilepsy has not been solved. As reported by Löscher: “to solve this problem, ….a better hypothesis of the basic mechanisms of pharmacoresistance are needed”. There is a clear medical need for new ideas, new mechanisms of action to serve as an alternative or adjunct therapy for the treatment of refractory epilepsy. I'm writing about a new idea.

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Seizure Differences
Written by doubledelightjs   
01 May 2008

The following is from a page in the magazine "Epilepsy Advocate":

Seizure types and causes vary greatly from person to person.  Two epilepsy specialists discus why understanding and identifying the differences is important to you and your doctor.



Hits: 1666
 

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