I have been on Cymbalta for about three months now.  It is so wonderfully awesome I can't say enough good things about it.  I wouldn't say I was having an episode of depression whenmy doctor put me on it, but rather I was having a lot of anxiety issues.  I told my doc about my RSD and other medical issues.  He immediately identified certain things about my illness.  With this he put me on Cymbalta.  I had no idea at the time how it would impact my RSD.

With this said, I should itterate that depression and RSD are highly correlated in studies.  Since it is social science, there is no causation assumed.  However, it makes sense that if you treat one, the other will be impacted.  Since there is no real treatment for RSD, the next best thing is to treat the commonality- the depression. 

As I said, I was not presenting with what I would consider a depressive episode.  So why would Cymbalta, a treatment for depression (and other things) create a sort of nerve block for my pain?  There is a whole biological explanation for this, but I am not qualified to speak about it.  The bottom line is this medication has truely helped me. 

I still have physiological problems, but I think that has more to do with my being more active.  My ankle swells up pretty bad, and is uncomfortable.  I also think the atrophy and the nerve damage have to go through a sort of growing pain to be repaired.  I also believe that I will be better again.